Brn3a protein
WebJun 29, 2024 · Brn3a is a member of the Brn3/Pou4f transcription factor family, which contains key regulators of RGC postmitotic specification. In particular, Brn3a ablation results in the loss of RGCs with small, thick and dense dendritic arbors ('midget-like' RGCs), and morphological changes in other RGC subpopulations. WebMar 21, 2024 · This protein is expressed in a subset of retinal ganglion cells and may be involved in the developing sensory nervous system. This protein may also …
Brn3a protein
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WebDec 14, 2005 · Guinea pig antisera to Brn3a were prepared against a glutathione S -transferase fusion protein containing an 80 amino acid fragment of mouse Brn3a containing sequences N-terminal to the POU-specific domain that are not conserved across members of the Brn3 (POU4) gene class. All Brn3-family antisera were antigen-affinity purified … WebFeb 15, 2007 · Brn3a binding to the Pou4f1 locus in vitro and in embryonic trigeminal ganglia. (A) Complex stability screening of a 188-kb BAC encompassing the Pou4f1 locus. BAC DNA was sheared by sonication and selected using recombinant Brn3a protein (Materials and methods). Fragments were ligated into a cloning vector, and 128 …
WebApr 9, 2024 · Recombinant Protein; Magnetic Beads; Ab Production. Anti-Idiotype Monoclonal Ab; GPCR Monoclonal Ab; Mouse, Rat & Rabbit Monoclonal Ab (All) Mouse, Rat & Rabbit Polyclonal Ab (All) Rabbit Monoclonal Ab (Phage) Camelid Single Domain Ab (Nanobody) DNAx™ Immune; SAMx™ Immune; Ab Scale-up. WebMar 7, 2014 · Brn3a and Brn3b are broadly expressed in early stages of development, but are restricted to correct target populations thereafter, and thus conventional Cre alleles will result in whole embryo recombination when used in conjunction with Cre dependent conditional alleles and reporter lines.
WebThe POU domain transcription factors Brn3a, Brn3b and Brn3c are required for the proper development of sensory ganglia, retinal ganglion cells, and inner ear hair cells, respectively. We have investigated the roles of Brn3a in neuronal differentiation and target innervation in the facial-stato-acoustic ganglion. WebThe neural crest transcription factor BRN3A is essential for the proliferation and survival of melanoma cells. It is frequently expressed in melanoma but not in normal melanocytes or …
WebJan 3, 2024 · The loss of BRN3a-positive RGCs was also reflected by a 30% decline in BRN3a protein expression. These were accompanied by reduced ERG amplitudes and PhNRs. Importantly, the diabetic retinas demonstrated increased expression of TRIB3 and level of p-AKT/p-mTOR axis but reduced level of IRS-1 protein. Therefore, a new non …
POU domain, class 4, transcription factor 1 (POU4F1) also known as brain-specific homeobox/POU domain protein 3A (BRN3A), homeobox/POU domain protein RDC-1 or Oct-T1 is a protein that in humans is encoded by the POU4F1 gene. BRN3A (POU4F1) is a class IV POU domain-containing transcription factor … See more Brn3a was initially discovered in mice based on homology to the prototypal POU transcription factors Pit1 (Pituitary-specific positive transcription factor 1, Pou1f1), Oct1 (Pou2f1), and the Caenorhabditis elegans factor … See more In addition to sensory neurons, in rodents and birds (and presumably humans) Brn3a is expressed in multiple sites in the central nervous system, … See more • BRN-3 See more • POU4F1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text from the United States National Library of Medicine See more POU4F1 has been shown to interact with Estrogen receptor alpha, RIT2 and Ewing sarcoma breakpoint region 1. See more • Eng SR, Lanier J, Fedtsova N, Turner EE (Aug 2004). "Coordinated regulation of gene expression by Brn3a in developing sensory ganglia". … See more customer service core competenciesWebOct 18, 2004 · The mechanism by which HIPK2 regulates Brn3a is mediated through protein–protein interaction, which suppresses the Brn3a-dependent transcription of brn3a, trkA, and bcl-x L loci. As a consequence, overexpression of HIPK2 mimics the phenotype of the Brn3a − / − mutants, resulting in apoptotic cell death in cultured sensory neurons. mariano dotelWebJan 1, 2024 · Using Brn3a and Brn3b mutant mice in which the alkaline phosphatase gene was knocked-in (Badea et al. [Neuron] 2009;61:852-864; Badea and Nathans [Vision Res] 2011;51:269-279), we studied the general effects after gene removal on the retinal neuropil together with the consequences of lack of development of large numbers of GCs onto the ... customer service communication videosWebJan 3, 2024 · The loss of BRN3a-positive RGCs was also reflected by a 30% decline in BRN3a protein expression. These were accompanied by reduced ERG amplitudes and PhNRs. Importantly, the diabetic retinas demonstrated increased expression of TRIB3 and level of p-AKT/p-mTOR axis but reduced level of IRS-1 protein. Therefore, a new non … customer service coordinator descriptionWebBrn3a can be used as a reliable, efficient ex vivo marker to identify and quantify RGCs in control and optic nerve-injured retinas. Brn3a as a marker of retinal ganglion cells: … mariano di vaio youngWebAnti-Brn-3a Antibody, POU-domain protein, clone 5A3.2 MAB1585 Sigma-Aldrich Anti-Brn-3a Antibody, POU-domain protein, clone 5A3.2 Download Zoom Anti-Brn-3a Antibody, POU-domain protein, clone 5A3.2 detects level of Brn-3a & has been published & validated for use in IH & WB. customer service costa coffeeWeb15 rows · Jan 5, 2024 · Brn-3a Antibody (C-20): sc-31984. 4.6 (9) Write a review Ask a question. Brn-3a Antibody (C-20) is a goat polyclonal IgG; 100 µg/ml. epitope mapping … customer service core values