Cd46 function
WebNX_P15529 - CD46 - Membrane cofactor protein - Function. Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against … WebOct 21, 2012 · CD46 functions as a pathogen receptor and is a potent costimulator for the induction of interferon-γ (IFN-γ)-secreting effector T helper type 1 (T H 1) cells and their subsequent switch into ...
Cd46 function
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WebDec 1, 2013 · The novel concept that surface expression of CD46 may function as ‘stop signal’ offers an intriguing explanation for the counterintuitive down-regulation of CD46 observed on most activated cell types (Gill et al., 2003): CD46 presence signifies a normal environment, while CD46 ‘disappearance’ indicates cell stimulation and provides a ... The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation (through cleavage) of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement.
WebCD46 (MCP, membrane cofactor protein) is a multifunctional cell surface transmembrane protein that binds and inactivates C3b and C4b complement fragments, regulates T cell … WebApr 13, 2011 · CD46 is expressed ubiquitously and functions as a co-factor in the factor I-mediated proteolytic cleavage of C3b and C4b. Its vital role in preventing complement …
WebCD46-associated functions are largely dependent on cell type and activation state. However, several studies have shown a role for CD46 in different signaling pathways in the same cell. This phenomenon can be explained by the presence of two different cytoplasmic tails that are co-expressed in the majority of cells. WebMembrane cofactor protein (MCP; CD46) is a widely distributed C3b/C4b-binding cell surface glycoprotein which serves as an inhibitor of complement activation on host cells. …
WebCD46 is a ubiquitous human cell surface receptor for the complement components C3b and C4b and for various pathogens, including the measles virus and human herpes virus 6. Ligand binding to CD46 affects (i) protection of autologous cells from complement attack by breakdown of complement components, (ii) intracellular signals that affect the regulation …
WebDec 31, 2024 · The function of CD46 was validated in infection experiments using cells lacking and overexpressing CD46, and by competition infection experiments using soluble CD46. Remarkably, unlike HAdV-B types that engage CD46 through interactions with the knob domain of the fiber protein, HAdV-D types infect host cells through a direct … marysville high school sportsWebSep 30, 2010 · CD46 protects autologous cells from complement attack by binding to complement proteins C3b and C4b and serving as a cofactor for their cleavage. Recent … hutools convertWebCD46 isoforms function as receptors for human herpesvirus 6 and measles virus Acts in cohort with fimbrial adhesion to promote the uptake of pathogenic Escherichia … hutools copy listWebCD46 (MCP, MGC26544, MIC10, TLX, TRA2.10) protein expression summary. We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. ... Molecular function (UniProt) i. Host cell receptor for virus entry, Receptor: Biological process (UniProt) i. Complement pathway, Fertilization ... hutools bcryptWebFeb 1, 2012 · The role of CD46 in so many important diseases underlines its importance in maintaining immune homeostasis, and highlights the need to further understand its function. Defects of CD46 in MS are not only confined to T cells. CD46-activation of dendritic cells (DCs) was also skewed towards a pro-inflammatory profile. marysville hole texasWebNov 15, 1994 · Evidence that CD46 and CD59 are immunogenic in macaques was found when anti-cell antibodies in plasmas from macaques immunized with human cell-grown SIV blocked anti-CD46 and anti-CD59 from binding to the surface of CEM x 174 cells. Anti-cell antibodies rendered HIV-1 susceptible to complement lysis as measured by the release … hutools copyWebMembrane cofactor protein (MCP; CD46) is a widely distributed C3b/C4b-binding cell surface glycoprotein which serves as an inhibitor of complement activation on host cells. The protein has been purified, multiple cDNAs cloned and sequenced, and the genomic organization determined. MCP belongs to a f … hutools copy文件