Cisplatin ic50

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August undefined, 2024

WebFeb 28, 2024 · All the new complexes showed cytotoxicity in vitro against the three cancer cell lines, but only complex 1a showed statistically significant different activity compared … WebPurpose: Alterations in the DNA mismatch repair (MMR) proteins have been associated with an increased resistance of many cancer cell lines to cisplatin. The aim of this work was …

IC50 and relative resistance of bladder cancer cell lines

WebOct 25, 2016 · To overcome severe MTT artifacts, we developed an unbiased direct IC50 measurement method, the limiting dilution assay. This detection technique led us to the … WebMar 22, 2024 · Cell viability and IC50 value were measured by MTT assay. Cell apoptosis was confirmed by flow cytometry assay. Subcellular fractionation assay was used to identify the subcellular location of TP53TG1. fish restaurants st charles il

Drug: Cisplatin - Cancerrxgene - Genomics of Drug Sensitivity in …

WebFeb 1, 2024 · Cisplatin injection is used to treat advanced cancer of the bladder, ovaries, or testicles. Cisplatin is an antineoplastic agent (cancer medicine). It interferes with the growth of cancer cells, which are eventually destroyed by the body. This medicine is to be given only by or under the direct supervision of a doctor. WebIC 50 values for cisplatin, curcuminoid, and combination treatments in A549 cell culture. Standard deviation values are provided after the ± symbol for each inhibitory … WebSome scientists established EC50 for cisplatin in SKOV-3 cell line, and it varied from 2 to 40 uM. However, in this publication there are some interesting data regarding that … fish restaurants southampton

Cisplatin remodels the tumor immune microenvironment via …

Cisplatin (NSC 119875) ≥99%(HPLC) - selleckchem

WebApr 11, 2024 · Group division and overview of cells’ IC50 value of cisplatin 661 cell lines were finally enrolled with the complete data of mRNA, microRNA expression, and metabolite. They were divided into 3 groups according to the IC50 value, the half inhibitory concentration, given by the CCLE database, which reflects the sensitivity to … WebApr 11, 2024 · IC50 was calculated with non-linear regression, and the survival rates were analyzed by log-rank test. The difference thresholds were set at p -value less 0.05 and p -value less 0.01. 3 Results 3.1 Proliferation of GC cells in alginate-based microspheres (core) candler oil lynchburg vaWebCisplatin (NSC 119875, Cisplatinum, cis-diamminedichloroplatinum II, CDDP, cis DDP, DDP) is an inorganic platinum complex, which is able to … fish restaurants st ives

"WebDownload scientific diagram Summary of IC50 values of sinomenine or cisplatin in gastric cancer cells. from publication: Sinomenine sensitizes human gastric cancer cells to … " - Cisplatin ic50

Cisplatin ic50

Anticancer effect of curcumin on breast cancer and stem cells

WebSep 1, 2015 · Cisplatin, an alkylating agent has been successfully used since decades for the treatment of variety of cancers viz. bone cancer, lung cancer, head and neck cancer, …

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WebCisplatin (DDP) is a common therapeutic option for non-small cell lung carcinoma (NSCLC). However, some patients fail to respond to the DDP chemotherapy. Therefore, identifying … WebJun 5, 2024 · We first analyzed the correlation between TFEB expression and half maximal inhibitory concentration (IC50) of CDDP using Genomics of Drug Sensitivity in Cancer …

WebOverexpressing miR-515-5p markedly reduced cisplatin and 5-Fu IC50 values in HK-1/CDDP and CNE-1/CDDP cells, while IL-25 transfection was sufficient to reverse this phenotype (Figure 4E and F). As such, our data demonstrate that circNRIP1 enhances 5-Fu and cisplatin resistance in NPC cells at least in part via sequestering miR-515-5p and ... WebThe IC50 values of the two platinum derivatives varied considerably. The values for cisplatin varied between 0.022 microgram ml-1 and 0.56 microgram ml-1 and the …

WebApr 10, 2024 · The half-maximal inhibitory concentration values (IC 50) were calculated by interpolation from the nonlinear regression curves obtained from cell proliferation/cytotoxicity data using “log (inhibitor) versus the normalized response–variable slope equation”. A p -value lower than 0.05 was considered statistically significant. 3. Results WebThe results of the present study show that 0.33 μmol/L cisplatin (IC 50) increased MN frequency by 2.5 times, compared to the non-treated control group. This indicates that cisplatin causes chromosomal mutations …

WebJun 15, 2024 · Methods: In this study, real-time quantitative PCR (RT-qPCR) and Western blotting (WB) were performed for detecting the expressions of miR-133b, fibroblast growth factor receptor 1 (FGFR1), and Wingless/Integrated (Wnt)-β-catenin pathway markers (Wnt1, β-catenin, nuclear-β-catenin, p-GSK-3β, GSK-3β, cyclinD1, and FOXQ1).

WebFeb 28, 2024 · All the new complexes showed cytotoxicity in vitro against the three cancer cell lines, but only complex 1a showed statistically significant different activity compared with cisplatin, with significantly lower IC 50 values, 4.31, 6.23, and 4.80 μM, compared with 9.71, 14.48, and 11.59 μM for cisplatin against A549, SKOV3, and MCF-7, respectively. candler pierceWebJan 10, 2024 · The half maximal inhibitory concentration (IC50) of different OC cells after treatment with ( a) olaparib, ( b) niraparib and ( c) rucaparib, assessed by clonogenic assays. Data represents the mean ± SEM of triplicates of … candler park restaurantsWebIC50 cisplatin concentration (mM) Source publication Lifeguard inhibition of Fas-mediated apoptosis: A possible mechanism for explaining the cisplatin resistance of triple … fish restaurants st pete beachWebAug 13, 2024 · CCK8 assay demonstrated that the half-maximal inhibitory concentration (IC50) of paclitaxel was 22.61 nM and 101.4 nM for NCI-H1975 and NCI-H1299 cells, … fish restaurants sudburyWebAfter an incubation with DDP/EXOs, the cell lines exhibited a higher IC50 value for cisplatin, P-gp expression, migration and invasion capabilities and a lower apoptosis … fish restaurants st ives cornwallWebThe SIN mean IC50 for HGC-27, SGC-7901, and BGC-803 at 24 hours was 372.60, 284.40, and 279.70 μM; The cisplatin mean IC50 for HGC-27, SGC-7901, and BGC-803 at 24 hours was 3.85, 3.13, and... fish restaurants st louis moWebIC50 values were calculated. Evaluation of apoptosis and DNA damage were performed. In addition, the expression of pro-apoptotic and anti-apoptotic genes and proteins were tested. IC50 values indicated less toxicity of the Schiff base … candler park houses for sale