WebSTABILITY STUDY OF PHOSLACTOMYCIN B AND ANALYSIS OF DEGRADATION PRODUCTS A thesis submitted in partial fulfillment of the requirements for the degree of Master of Science at Virginia Commonwealth University By Suparna Das Choudhuri B.Pharm., Rajiv Gandhi University of Health Sciences, 2001 Director: Kevin A Reynolds, Ph.D. WebA Biblioteca Virtual em Saúde é uma colecao de fontes de informacao científica e técnica em saúde organizada e armazenada em formato eletrônico nos países da Região Latino-Americana e do Caribe, acessíveis de forma universal na Internet de modo compatível com as bases internacionais.
Synthetic Strategies Employed for the Construction of Fostriecin …
WebFeb 2, 2007 · The majority of modular polyketide synthase (PKS) systems which generate unsaturated products do so with trans double bonds. Phoslactomycin B (PLM B) presents a class of antitumor and antiviral natural polyketide products that have unique structural features, including a linear unsaturated backbone with one trans and three cis double … WebPhoslactomycin is a natural product from the isolation of Streptomyces species. This is an inhibitor of the protein serine/threonine phosphatase which is the protein phosphate 2A . … crystal charity ball dallas 2021
Asymmetric Total Synthesis of (+)-Phoslactomycin B
WebDec 8, 2016 · One of the unique challenges for the synthesis of phoslactomycin B and the other cyclohexane-containing members of the family is the ethyl amino substituent at C8. This added challenge, common to the phoslactomycins, phosphazomycins, and leustroducsins, has been met by using a variety of strategies, including installation of an … WebSep 1, 2005 · Phoslactomycin B (PLM-B), a potent and selective inhibitor of serine threonine phosphatase is of interest for its antitumor, antifungal and antiviral activity. Described … WebFeb 21, 2024 · Lactomycins exhibited cathepsin B inhibitory activity (IC50 0.8 to 4.5 μg/mL). Even though the biosynthetic gene clusters found in the genome of the current strain have high similarity to those of phoslactomycin, neither phoslactomycins nor leustroducsins were detected by LC-MS analyses of the crude extract. dvs tfl contact number